2011 Warren Prize Winner
Frits Koning, Ph.D., head of the Immunochemistry Section in the Department of Immunohematology and Blood Transfusion of the Leiden University Medical Centre (LUMC), the Netherlands, is recipient of the 2011 William K. Warren, Jr. Prize for Excellence in Celiac Disease Research. Professor Koning was presented with the award by Mr. William K. Warren, Jr. and gave the 2011 Warren Prize Lecture, "Celiac Disease: How complicated can it get?", on June 3, 2011.
Lectures Available online
The Warren Celiac Center has held a series of free community lectures over the past few years. They were filmed, and aired on UCSD-TV. They are also available for online viewing at UCSD-TV and on Youtube.com. Below are the links for each year's program and a program description.
2010 Community Lecture: "Celiac Disease and Gluten: Facts, Fiction & Controversies”
Date: November 2, 2010
Celiac disease is an inflammatory autoimmune disorder of the small intestine triggered by gluten, a protein found in wheat, rye and barley. Celiac disease is an inflammatory autoimmune disorder of the small intestine triggered by gluten, a protein found in wheat, rye and barley. With symptoms that vary from person to person, it's a disease that often remains undiagnosed. Join Martin Kagnoff, one of the country's leading authorities in Celiac disease research, Kimberly Newton, a pediatric gastroenterologist, and dietitian Shawna McNally for a detailed discussion about the disease and its many misconceptions.
2008 Community Lecture: "Understanding Celiac Disease & Gluten Sensitivity: Your Gut Reaction”
Date: October 28, 2008
Celiac disease is an inflammatory condition of the small intestine triggered by the consumption of gluten, a dietary protein found in wheat, rye, and barley. It is estimated that 85% of the people in the U.S. with celiac disease remain undiagnosed. In this program, experts from the Wm. K. Warren Medical Research Center for Celiac Disease at UCSD help us to understand this disease. Martin F. Kagnoff, M.D., one of the country's leading authorities, and director of the center, discusses the role of various tests in diagnosis, how celiac disease affects the body, as well as gluten intolerance and wheat allergy in the absence of celiac disease. Kimberly P. Newton, M.D., Pediatric Gastroenterologist and director of the pediatric celiac clinic at Rady Children's Hospital in San Diego, covers special aspects of celiac disease in children. The Center's former dietitian shares how to keep celiac disease under control with a gluten-free diet.
2007 Community Lecture: "What You Need to Know About Celiac Disease and the Gluten-Free Diet”
Date: September 19, 2007
Can bread, pasta, cookies, pizza crust make you sick? The answer for 1 out of 100 people in the U.S. is yes. For this group, celiac disease, a frequently misdiagnosed digestive condition, is the cause. Join us for a thorough overview of the disease featuring recognized experts in the field presented by UCSD’s Wm. K. Warren Medical Research Center for Celiac Disease. Speakers include: Martin F. Kagnoff, M.D., one of the country’s leading authorities in Celiac Disease research, presenting on how this disease affects the body. Gregory S. Harmon, M.D., Gastroenterologist, covers diagnosis and treatment. The Center's former dietitian shares how to keep the disease under control with a gluten-free diet.
For more information, click [HERE] for the UCSD-TV website.
The study, “TLR3, TRIF, and Caspase 8 Determine Double-Stranded RNA-Induced Epithelial Cell Death and Survival in Vivo,” shows that double-stranded RNA (dsRNA), which is characteristic of certain viral infections, activates a Toll-like receptor 3 (TLR3) signaling pathway in the intestinal epithelial cells (IECs) that line the small intestine and results in the death of those cells. IECs form the surface lining of small intestinal villi, which are finger-like projections that increase the surface area available for the absorption of nutrients from digested food. It is those IECs that are the targets of the dsRNA-induced cell death, which results in shortening of the villi and diarrhea. Disorders of the small intestine, such as celiac disease and certain intestinal virus infections (e.g. Rotavirus infection) are characterized by villus shortening in the small intestine and abnormalities in the absorption of nutrients. Epithelial cell death occurred by a process known as apoptosis, which is a type of programmed cell death. Importantly, despite these dramatic changes to the small intestine, the damage to the small intestinal structure was transient, since mice exposed to dsRNA survived and intestinal structure returned to normal within 48 hours. The researchers found that signaling induced by dsRNA occurred through TLR3 and the adaptor molecule TRIF and was preceded by increased activation of caspase 3 and 8 in the epithelial cells. Those caspases are enzymes that mediate apoptosis by cleaving cellular proteins. The scientists discovered that mice lacking TLR3 or its downstream adaptor TRIF were completely protected from dsRNA-induced IEC apoptosis. Further, they demonstrated that caspase 8 signaling in IECs was required for IEC apoptosis and recovery from villus shortening as mice lacking caspase 8 in IECs developed complete epithelial destruction in the small intestine and died. This finding suggests that intact caspase 8 signaling in the epithelium serves a protective function in response to dsRNA-activated signaling. They showed that IEC apoptosis was independent of other signaling mechanisms, leading the researchers to conclude that dsRNA activation of the TLR3-TRIF-caspase 8 signaling pathway in IECs has a significant impact on the structure and function of small intestinal mucosa. The authors suggest that signaling through this pathway may play a protective role during infection with viral pathogens, whereby increased IEC death and fluid loss may result in reduced viral load in the small intestine. Other contributors to the study include first author Christopher S. McAllister, and Omar Lakhdari, Guillaume Pineton de Chambrun, Mélanie G. Gareau, Alexis Broquet, Gin Hyug Lee, Steven Shenouda, and Lars Eckmann. The study was supported by National Institutes of Health Grants DK35108 and DK80506 and by a grant from the William K. Warren Foundation.
Celiac Disease Screening/Research Study
Community Screening Program/Research Study for Celiac Disease -*THIS STUDY IS NOW CLOSED
San Diego Gluten-Free Expo 2013
Keep visiting our website for more information about this event.
San Diego Gluten-Free Expo 2011
Check out the video from San Diego Gluten-Free Expo 2011:
Testing for Celiac Disease
Click [HERE] for a one-page printable PDF document on testing for celiac disease.
CELIAC DISEASE RESEARCH/NEWS
National Institutes of Health - Celiac Disease Awareness Campaign ( From the National Digestive Diseases Information Clearinghouse A service of the National Institute of Diabetes and Digestive and Kidney Diseases)
Educational Materials and Resources
Testing for Celiac Disease (for providers) [HTML]
Dermatitis Herpetiformis: Skin Manifestation of Celiac Disease [HTML]
What I need to know about Celiac Disease [HTML]
What I Need to Know about Celiac Disease (Spanish) [HTML]
Celiac Disease -A fact sheet [HTML]
The Gluten Free Diet - Some Examples [HTML file]
Celiac Disease: What You Need to Know [HTML]
NIH Consensus Statement on Celiac Disease [HTML]
(2012) Can Consumers Trust Web-Based Information About Celiac Disease?
Read more about the recently published journal title "Can Consumers Trust Web-Based Information About Celiac Disease? Accuracy, Comprehensiveness, Transparency, and Readability of Information on the Internet"
Authors: McNally SL, Donohue MC, Newton KP, Ogletree SP, Conner KK, Ingegneri SE, Kagnoff MF Can Consumers Trust Web-Based Information About Celiac Disease? Accuracy, Comprehensiveness, Transparency, and Readability of Information on the Internet Interact J Med Res 2012;1(1):e1
About Celiac Disease
Celiac Disease is an immune-mediated disorder that affects primarily the gastrointestinal tract in individuals of all ages. The classic description of a child with Celiac Disease was one who was irritable, with profound abdominal distention, gluteal wasting, and failure to thrive or in adults, profound malabsorption and weight loss.
It is now recognized that Celiac Disease affects other organ systems causing disease without overt GI symptoms, which adds a diagnostic challenge to healthcare providers caring for patients with Celiac Disease.
It is important to consider the diagnosis when faced not only with patients who present with GI symptoms, but also additional non-intestinal symptoms that do not respond reasonably to conventional type therapies.
For a printable PDF file with information on San Diego Area Celiac Disease Support Groups, click [here]
For information about local meetings, speakers, special events, activities, etc, go to http://glutenfreeinsd.com/sd_support_groups.html
Celiac Disease Foundation (CDF), Hemet Chapter
Email:Jenny Darby, email@example.com
This group meets on the 2nd Saturday of every month at the Red Robin (1900 W. Florida Avenue Hemet, CA 92545)
National Support Groups:
Celiac Disease Foundation (CDF)
To find a support group in your area of the country, click on Local Support
For a list of Celiac Disease Centers and experts across the United States, click [here]